A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxe...

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Autores principales: Han, Yang, Liang, Na, Yan, Pengfei, Kawashima, Yoshiaki, Cui, Fude, Sun, Shaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077419/
https://www.ncbi.nlm.nih.gov/pubmed/32046268
http://dx.doi.org/10.3390/polym12020380
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author Han, Yang
Liang, Na
Yan, Pengfei
Kawashima, Yoshiaki
Cui, Fude
Sun, Shaoping
author_facet Han, Yang
Liang, Na
Yan, Pengfei
Kawashima, Yoshiaki
Cui, Fude
Sun, Shaoping
author_sort Han, Yang
collection PubMed
description In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.
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spelling pubmed-70774192020-03-20 A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel Han, Yang Liang, Na Yan, Pengfei Kawashima, Yoshiaki Cui, Fude Sun, Shaoping Polymers (Basel) Article In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX. MDPI 2020-02-08 /pmc/articles/PMC7077419/ /pubmed/32046268 http://dx.doi.org/10.3390/polym12020380 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Han, Yang
Liang, Na
Yan, Pengfei
Kawashima, Yoshiaki
Cui, Fude
Sun, Shaoping
A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_full A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_fullStr A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_full_unstemmed A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_short A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_sort chitosan-based micellar system as nanocarrier for the delivery of paclitaxel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077419/
https://www.ncbi.nlm.nih.gov/pubmed/32046268
http://dx.doi.org/10.3390/polym12020380
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