Pentamidine niosomes thwart S100B effects in human colon carcinoma biopsies favouring wtp53 rescue

S100B protein bridges chronic mucosal inflammation and colorectal cancer given its ability to activate NF‐kappaB transcription via RAGE signalling and sequestrate pro‐apoptotic wtp53. Being an S100B inhibitor, pentamidine antagonizes S100B‐wtp53 interaction, restoring wtp53‐mediated pro‐apoptotic co...

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Detalles Bibliográficos
Autores principales: Seguella, Luisa, Rinaldi, Federica, Marianecci, Carlotta, Capuano, Riccardo, Pesce, Mirella, Annunziata, Giuseppe, Casano, Fabrizio, Bassotti, Gabrio, Sidoni, Angelo, Milone, Marco, Aprea, Giovanni, de Palma, Giovanni Domenico, Carafa, Maria, Pesce, Marcella, Esposito, Giuseppe, Sarnelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077541/
https://www.ncbi.nlm.nih.gov/pubmed/32022398
http://dx.doi.org/10.1111/jcmm.14943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077541/
https://www.ncbi.nlm.nih.gov/pubmed/32022398
http://dx.doi.org/10.1111/jcmm.14943

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