Knockout of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative stem cell disorder characterized by the constitutively active BCR‐ABL tyrosine kinase. The LIM and SH3 domain protein 1 (LASP1) has recently been identified as a novel BCR‐ABL substrate and is associated with proliferation, migration, tu...

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Detalles Bibliográficos
Autores principales: Herrmann, Andreas B., Müller, Martha‐Lena, Orth, Martin F., Müller, Jörg P., Zernecke, Alma, Hochhaus, Andreas, Ernst, Thomas, Butt, Elke, Frietsch, Jochen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077607/
https://www.ncbi.nlm.nih.gov/pubmed/31957290
http://dx.doi.org/10.1111/jcmm.14910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077607/
https://www.ncbi.nlm.nih.gov/pubmed/31957290
http://dx.doi.org/10.1111/jcmm.14910

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