Integration of Polylactide into Polyethylenimine Facilitates the Safe and Effective Intracellular siRNA Delivery

Polyethylenimine (PEI) is a gold standard polymer with excellent transfection efficacy, yet its severe toxicity and nondegradability hinders its therapeutic application as a gene delivery vector. To tackle this problem, herein we incorporated the biodegradable polylactide (PLA) into the branched PEI...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Guo-Bin, Meng, Xue, Yang, Peng, Li, Binchun, Stauber, Roland H, Li, Zhuoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077636/
https://www.ncbi.nlm.nih.gov/pubmed/32074943
http://dx.doi.org/10.3390/polym12020445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077636/
https://www.ncbi.nlm.nih.gov/pubmed/32074943
http://dx.doi.org/10.3390/polym12020445

Ejemplares similares