Cargando…

Integration of Polylactide into Polyethylenimine Facilitates the Safe and Effective Intracellular siRNA Delivery

Polyethylenimine (PEI) is a gold standard polymer with excellent transfection efficacy, yet its severe toxicity and nondegradability hinders its therapeutic application as a gene delivery vector. To tackle this problem, herein we incorporated the biodegradable polylactide (PLA) into the branched PEI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Guo-Bin, Meng, Xue, Yang, Peng, Li, Binchun, Stauber, Roland H, Li, Zhuoyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077636/ https://www.ncbi.nlm.nih.gov/pubmed/32074943 http://dx.doi.org/10.3390/polym12020445

Ejemplares similares

Hydroxyethyl substituted linear polyethylenimine for safe and efficient delivery of siRNA therapeutics
por: Patil, Sushilkumar, et al.
Publicado: (2018)

cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy
por: Yang, Shuang, et al.
Publicado: (2021)

Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics
por: Shen, Jianliang, et al.
Publicado: (2014)

Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles
por: Zhang, Ruirui, et al.
Publicado: (2022)

Polymeric Nanoparticles Based on Tyrosine-Modified, Low Molecular Weight Polyethylenimines for siRNA Delivery
por: Ewe, Alexander, et al.
Publicado: (2019)

Polyethylenimine-Conjugated Hydroxyethyl Cellulose for Doxorubicin/Bcl-2 siRNA Co-Delivery Systems
por: Park, Jiwon, et al.
Publicado: (2023)

Effective Non-Viral Delivery of siRNA to Acute Myeloid Leukemia Cells with Lipid-Substituted Polyethylenimines
por: Landry, Breanne, et al.
Publicado: (2012)

Enhanced Gene Silencing through Human Serum Albumin-Mediated Delivery of Polyethylenimine-siRNA Polyplexes
por: Nicolì, Elena, et al.
Publicado: (2015)

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine
por: Xie, Yuran, et al.
Publicado: (2016)

Branched polyethylenimine-grafted-carboxymethyl chitosan copolymer enhances the delivery of pDNA or siRNA in vitro and in vivo
por: Park, Seong-Cheol, et al.
Publicado: (2013)

Superparamagnetic iron oxide nanoparticles modified with polyethylenimine and galactose for siRNA targeted delivery in hepatocellular carcinoma therapy
por: Yang, Zhen, et al.
Publicado: (2018)

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease
por: Helmschrodt, Christin, et al.
Publicado: (2017)

Inhibition of Tumor Growth via Systemic siRNA Delivery Using Reducible Bile Acid-Conjugated Polyethylenimine
por: Yin, Yue, et al.
Publicado: (2018)

Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
por: Levine, Rachel M., et al.
Publicado: (2016)

Intracellular Delivery of siRNA by Polycationic Superparamagnetic Nanoparticles
por: Castillo, Betzaida, et al.
Publicado: (2012)

Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles
por: Kummitha, China M, et al.
Publicado: (2012)

Modular and hierarchical self-assembly of siRNAs into supramolecular nanomaterials for soft and homogeneous siRNA loading and precise and visualized intracellular delivery
por: Guan, Xiaowen, et al.
Publicado: (2022)

Versatility of cell-penetrating peptides for intracellular delivery of siRNA
por: Singh, Tejinder, et al.
Publicado: (2018)

Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro
por: Fernandes, Julio C, et al.
Publicado: (2013)

Nischarin-siRNA delivered by polyethylenimine-alginate nanoparticles accelerates motor function recovery after spinal cord injury
por: Ding, Yue-min, et al.
Publicado: (2017)

Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
por: Khatri, N., et al.
Publicado: (2012)

Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery
por: Wang, Yingying, et al.
Publicado: (2023)

Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines
por: Parmar, Manoj B., et al.
Publicado: (2015)

Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA
por: Li, Jin-Ming, et al.
Publicado: (2013)

Development and characterization of chitosan-PEG-TAT nanoparticles for the intracellular delivery of siRNA
por: Malhotra, Meenakshi, et al.
Publicado: (2013)

Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown
por: Noske, Sandra, et al.
Publicado: (2020)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

Dendrimers for siRNA Delivery
por: Biswas, Swati, et al.
Publicado: (2013)

Folate-Mediated Targeted Delivery of siPLK1 by Leucine-Bearing Polyethylenimine
por: Hou, Lu, et al.
Publicado: (2020)

Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery
por: Tuttolomondo, Martina, et al.
Publicado: (2017)

Inter-molecular β-sheet structure facilitates lung-targeting siRNA delivery
por: Zhou, Jihan, et al.
Publicado: (2016)

Carbonate Apatite Nanoparticles-Facilitated Intracellular Delivery of siRNA(s) Targeting Calcium Ion Channels Efficiently Kills Breast Cancer Cells
por: Uddin, Mohammad Borhan, et al.
Publicado: (2018)

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
por: Biscans, Annabelle, et al.
Publicado: (2021)

Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA
por: Zang, Xinlong, et al.
Publicado: (2016)

Performance of Pyridylthiourea‐Polyethylenimine Polyplex for siRNA‐Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models
por: Gossart, Jean Baptiste, et al.
Publicado: (2017)

Molecularly engineered tumor acidity-responsive plant toxin gelonin for safe and efficient cancer therapy
por: Ding, Guo-Bin, et al.
Publicado: (2022)

Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer
por: Luo, Xin, et al.
Publicado: (2017)

Aptamer mediated siRNA delivery
por: Chu, Ted C., et al.
Publicado: (2006)

Pulmonary delivery of therapeutic siRNA
por: Lam, Jenny Ka-Wing, et al.
Publicado: (2012)

Intranasal Delivery of Antiviral siRNA
por: Barik, Sailen
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_odq6mqmm897e6l0ob1jnatkpfs