R409K mutation prevents acid-induced aggregation of human IgG4

Human immunoglobulin G isotype 4 (IgG4) antibodies are suitable for use in either the antagonist or agonist format because their low effector functions prevent target cytotoxicity or unwanted cytokine secretion. However, while manufacturing therapeutic antibodies, they are exposed to low pH during p...

Descripción completa

Detalles Bibliográficos
Autores principales: Namisaki, Hiroshi, Saito, Seiji, Hiraishi, Keiko, Haba, Tomoko, Tanaka, Yoshitaka, Yoshida, Hideaki, Iida, Shigeru, Takahashi, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077836/
https://www.ncbi.nlm.nih.gov/pubmed/32182240
http://dx.doi.org/10.1371/journal.pone.0229027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077836/
https://www.ncbi.nlm.nih.gov/pubmed/32182240
http://dx.doi.org/10.1371/journal.pone.0229027

Ejemplares similares