Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity

Mitochondrial dysfunction is implicated in the pathogenesis of multiple neurological diseases, but elucidation of underlying mechanisms is limited experimentally by the inability to damage specific mitochondria in defined neuronal groups. We developed a precision chemoptogenetic approach to target n...

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Detalles Bibliográficos
Autores principales: Xie, Wenting, Jiao, Binxuan, Bai, Qing, Ilin, Vladimir A, Sun, Ming, Burton, Charles E, Kolodieznyi, Dmytro, Calderon, Michael J, Stolz, Donna B, Opresko, Patricia L, St Croix, Claudette M, Watkins, Simon, Van Houten, Bennett, Bruchez, Marcel P, Burton, Edward A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077989/
https://www.ncbi.nlm.nih.gov/pubmed/32180546
http://dx.doi.org/10.7554/eLife.51845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077989/
https://www.ncbi.nlm.nih.gov/pubmed/32180546
http://dx.doi.org/10.7554/eLife.51845

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