A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

Mitochondria generate ATP and building blocks for cell growth and regeneration, using pyruvate as the main substrate. Here we introduce PyronicSF, a user-friendly GFP-based sensor of improved dynamic range that enables real-time subcellular quantitation of mitochondrial pyruvate transport, concentra...

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Detalles Bibliográficos
Autores principales: Arce-Molina, Robinson, Cortés-Molina, Francisca, Sandoval, Pamela Y, Galaz, Alex, Alegría, Karin, Schirmeier, Stefanie, Barros, L Felipe, San Martín, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077990/
https://www.ncbi.nlm.nih.gov/pubmed/32142409
http://dx.doi.org/10.7554/eLife.53917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077990/
https://www.ncbi.nlm.nih.gov/pubmed/32142409
http://dx.doi.org/10.7554/eLife.53917

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