Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation

Programmed cell death-1 (PD-1) inhibits T cell responses. This function relies on interaction with SHP-2. PD-1 has one immunoreceptor tyrosine-based inhibitory motif (ITIM) at Y223 and one immunoreceptor tyrosine-based switch motif (ITSM) at Y248. Only ITSM-Y248 is indispensable for PD-1-mediated in...

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Detalles Bibliográficos
Autores principales: Patsoukis, Nikolaos, Duke-Cohan, Jonathan S., Chaudhri, Apoorvi, Aksoylar, Halil-Ibrahim, Wang, Qi, Council, Asia, Berg, Anders, Freeman, Gordon J., Boussiotis, Vassiliki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078208/
https://www.ncbi.nlm.nih.gov/pubmed/32184441
http://dx.doi.org/10.1038/s42003-020-0845-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078208/
https://www.ncbi.nlm.nih.gov/pubmed/32184441
http://dx.doi.org/10.1038/s42003-020-0845-0

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