Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving h...

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Detalles Bibliográficos
Autores principales: Powley, Ian R., Patel, Meeta, Miles, Gareth, Pringle, Howard, Howells, Lynne, Thomas, Anne, Kettleborough, Catherine, Bryans, Justin, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078311/
https://www.ncbi.nlm.nih.gov/pubmed/31894140
http://dx.doi.org/10.1038/s41416-019-0672-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078311/
https://www.ncbi.nlm.nih.gov/pubmed/31894140
http://dx.doi.org/10.1038/s41416-019-0672-6

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