The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Alpha-synuclein (aSyn)-rich aggregates propagate in neuronal networks and compromise cellular homeostasis leading to synucleinopathies such as Parkinson’s disease. Aggregated aSyn spread follows a conserved spatio-temporal pattern that is not solely dependent on connectivity. Hence, the differential...

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Detalles Bibliográficos
Autores principales: Courte, Josquin, Bousset, Luc, Boxberg, Ysander Von, Villard, Catherine, Melki, Ronald, Peyrin, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078319/
https://www.ncbi.nlm.nih.gov/pubmed/32184415
http://dx.doi.org/10.1038/s41598-020-61757-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078319/
https://www.ncbi.nlm.nih.gov/pubmed/32184415
http://dx.doi.org/10.1038/s41598-020-61757-x

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