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The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Alpha-synuclein (aSyn)-rich aggregates propagate in neuronal networks and compromise cellular homeostasis leading to synucleinopathies such as Parkinson’s disease. Aggregated aSyn spread follows a conserved spatio-temporal pattern that is not solely dependent on connectivity. Hence, the differential...

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Detalles Bibliográficos
Autores principales:	Courte, Josquin, Bousset, Luc, Boxberg, Ysander Von, Villard, Catherine, Melki, Ronald, Peyrin, Jean-Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078319/ https://www.ncbi.nlm.nih.gov/pubmed/32184415 http://dx.doi.org/10.1038/s41598-020-61757-x

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