Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration

BACKGROUND: Monocarboxylate transporter 1 (MCT1) is a regulator of cell metabolism and a therapeutic target for cancer treatment. Understanding the changes in tumour function accompanying MCT1 inhibition will better characterise the anti-tumour effects of MCT1 inhibitors, potentially enabling the id...

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Detalles Bibliográficos
Autores principales: Beloueche-Babari, Mounia, Casals Galobart, Teresa, Delgado-Goni, Teresa, Wantuch, Slawomir, Parkes, Harold G., Tandy, Debbie, Harker, James A., Leach, Martin O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078321/
https://www.ncbi.nlm.nih.gov/pubmed/31937921
http://dx.doi.org/10.1038/s41416-019-0717-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078321/
https://www.ncbi.nlm.nih.gov/pubmed/31937921
http://dx.doi.org/10.1038/s41416-019-0717-x

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