Selective Inhibition of HDAC1 by Macrocyclic Polypeptide for the Treatment of Glioblastoma: A Binding Mechanistic Analysis Based on Molecular Dynamics

Glioblastoma (GBM) is the most common and aggressive intracranial malignant brain tumor, and the abnormal expression of HDAC1 is closely correlated to the progression, recurrence and metastasis of GBM cells, making selective inhibition of HDAC1 a promising strategy for GBM treatments. Among all avai...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Fu, Tingting, Ren, Yuxiang, Li, Fengcheng, Zheng, Guoxun, Hong, Jiajun, Yao, Xiaojun, Xue, Weiwei, Zhu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078330/
https://www.ncbi.nlm.nih.gov/pubmed/32219100
http://dx.doi.org/10.3389/fmolb.2020.00041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078330/
https://www.ncbi.nlm.nih.gov/pubmed/32219100
http://dx.doi.org/10.3389/fmolb.2020.00041

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