A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to wh...

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Detalles Bibliográficos
Autores principales: Chambers, Schuyler A., Moore, Rebecca E., Craft, Kelly M., Thomas, Harrison C., Das, Rishub, Manning, Shannon D., Codreanu, Simona G., Sherrod, Stacy D., Aronoff, David M., McLean, John A., Gaddy, Jennifer A., Townsend, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078465/
https://www.ncbi.nlm.nih.gov/pubmed/32184236
http://dx.doi.org/10.1128/mBio.00076-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078465/
https://www.ncbi.nlm.nih.gov/pubmed/32184236
http://dx.doi.org/10.1128/mBio.00076-20

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