Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer’s disease (AD) and other tauopathies. Full‐length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have shown...

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Detalles Bibliográficos
Autores principales: Al‐Hilaly, Youssra K., Foster, Bronwen E., Biasetti, Luca, Lutter, Liisa, Pollack, Saskia J., Rickard, Janet E., Storey, John M. D., Harrington, Charles R., Xue, Wei‐Feng, Wischik, Claude M., Serpell, Louise C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078754/
https://www.ncbi.nlm.nih.gov/pubmed/31721178
http://dx.doi.org/10.1002/1873-3468.13675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078754/
https://www.ncbi.nlm.nih.gov/pubmed/31721178
http://dx.doi.org/10.1002/1873-3468.13675

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