Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study

A method for the simultaneous determination of parecoxib and its metabolite valdecoxib in beagle plasma by UPLC-MS/MS was developed and validated. After the plasma was extracted by acetonitrile precipitation, the analytes were separated on an Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) usin...

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Detalles Bibliográficos
Autores principales: Li, Shuang-long, Zhu, Yong-liang, Zhu, Chun-yang, Li, Shao-bin, Li, Zi-heng, Qiu, Xiang-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078782/
https://www.ncbi.nlm.nih.gov/pubmed/32214797
http://dx.doi.org/10.2147/DDDT.S226349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078782/
https://www.ncbi.nlm.nih.gov/pubmed/32214797
http://dx.doi.org/10.2147/DDDT.S226349

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