Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Despite extensive research conducted to increase protein production from Chinese hamster ovary (CHO) cells, cellular bottlenecks often remain, hindering high yields. In this study, a transcriptomic analysis led to the identification of 32 genes that are consistently upregulated in high producer clon...

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Detalles Bibliográficos
Autores principales: Berger, Audrey, Le Fourn, Valérie, Masternak, Jacqueline, Regamey, Alexandre, Bodenmann, Iris, Girod, Pierre‐Alain, Mermod, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079004/
https://www.ncbi.nlm.nih.gov/pubmed/31956982
http://dx.doi.org/10.1002/bit.27274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079004/
https://www.ncbi.nlm.nih.gov/pubmed/31956982
http://dx.doi.org/10.1002/bit.27274

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