Anti‐TNF treatment negatively regulates human CD4(+) T‐cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype

TNF‐blockade has shown clear therapeutic value in rheumatoid arthritis and other immune‐mediated inflammatory diseases, however its mechanism of action is not fully elucidated. We investigated the effects of TNF‐blockade on CD4(+) T cell activation, maturation, and proliferation, and assessed whethe...

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Detalles Bibliográficos
Autores principales: Povoleri, Giovanni A. M., Lalnunhlimi, Sylvine, Steel, Kathryn J. A., Agrawal, Shweta, O'Byrne, Aoife M., Ridley, Michael, Kordasti, Shahram, Frederiksen, Klaus S., Roberts, Ceri A., Taams, Leonie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Immunomodulation and immune therapies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079027/
https://www.ncbi.nlm.nih.gov/pubmed/31722123
http://dx.doi.org/10.1002/eji.201948190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079027/
https://www.ncbi.nlm.nih.gov/pubmed/31722123
http://dx.doi.org/10.1002/eji.201948190

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