Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation

HIV‐1 Tat is essential for HIV‐1 replication and appears to play an important role in the pathogenesis of HIV‐associated neurological complications. Secreted from infected or transfected cells, Tat has the extraordinary ability to cross the plasma membrane. In the brain, Tat can be taken up by CNS c...

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Detalles Bibliográficos
Autores principales: Khan, Nabab, Halcrow, Peter W., Lakpa, Koffi L., Afghah, Zahra, Miller, Nicole M., Dowdy, Steven F., Geiger, Jonathan D., Chen, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079041/
https://www.ncbi.nlm.nih.gov/pubmed/31950548
http://dx.doi.org/10.1096/fj.201902534R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079041/
https://www.ncbi.nlm.nih.gov/pubmed/31950548
http://dx.doi.org/10.1096/fj.201902534R

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