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Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation
HIV‐1 Tat is essential for HIV‐1 replication and appears to play an important role in the pathogenesis of HIV‐associated neurological complications. Secreted from infected or transfected cells, Tat has the extraordinary ability to cross the plasma membrane. In the brain, Tat can be taken up by CNS c...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079041/ https://www.ncbi.nlm.nih.gov/pubmed/31950548 http://dx.doi.org/10.1096/fj.201902534R |