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Power gains by using external information in clinical trials are typically not possible when requiring strict type I error control
In the era of precision medicine, novel designs are developed to deal with flexible clinical trials that incorporate many treatment strategies for multiple diseases in one trial setting. This situation often leads to small sample sizes in disease‐treatment combinations and has fostered the discussio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079072/ https://www.ncbi.nlm.nih.gov/pubmed/31265159 http://dx.doi.org/10.1002/bimj.201800395 |