Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o(2) sensing, molecular switch

BACKGROUND: Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-translational modification system. In the adaptive immune response, B cells (Bc...

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Detalles Bibliográficos
Autores principales: Hilchey, Shannon P, Palshikar, Mukta G, Emo, Jason A, Li, Dongmei, Garigen, Jessica, Wang, Jiong, Mendelson, Eric S, Cipolla, Valentina, Thakar, Juilee, Zand, Martin S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079363/
https://www.ncbi.nlm.nih.gov/pubmed/32183695
http://dx.doi.org/10.1186/s12865-020-0342-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079363/
https://www.ncbi.nlm.nih.gov/pubmed/32183695
http://dx.doi.org/10.1186/s12865-020-0342-8

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