Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

BACKGROUND: Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating epileptogenesis. We previously found that dynorphins pro...

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Detalles Bibliográficos
Autores principales: Liu, Lin, Xu, Yingtong, Dai, Hongmei, Tan, Shan, Mao, Xiao, Chen, Zhiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079364/
https://www.ncbi.nlm.nih.gov/pubmed/32206297
http://dx.doi.org/10.1186/s13578-020-00387-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079364/
https://www.ncbi.nlm.nih.gov/pubmed/32206297
http://dx.doi.org/10.1186/s13578-020-00387-2

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