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High-level expression and characterization of an anti-VEGF165 single-chain variable fragment (scFv) by small ubiquitin-related modifier fusion in Escherichia coli
Antibodies currently constitute the most rapidly growing class of human therapeutics; however, the high-yield production of recombinant antibodies and antibody fragments is a real challenge. High expression of active single-chain antibody fragment (scFv) in Escherichia coli has not been successful,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079844/ https://www.ncbi.nlm.nih.gov/pubmed/18795288 http://dx.doi.org/10.1007/s00253-008-1655-3 |