5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production

A series of 5-substituted 2-amino-4,6-dihydroxypyrimidines were prepared by a modified condensation of the corresponding monosubstituted malonic acid diesters with guanidine in an excess of sodium ethoxide. The optimized procedure using Vilsmeier–Haack–Arnold reagent, followed by immediate deprotect...

Descripción completa

Detalles Bibliográficos
Autores principales: Jansa, Petr, Holý, Antonín, Dračínský, Martin, Kolman, Viktor, Janeba, Zlatko, Kostecká, Petra, Kmoníčková, Eva, Zídek, Zdeněk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080047/
https://www.ncbi.nlm.nih.gov/pubmed/32214763
http://dx.doi.org/10.1007/s00044-014-1018-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080047/
https://www.ncbi.nlm.nih.gov/pubmed/32214763
http://dx.doi.org/10.1007/s00044-014-1018-9

Ejemplares similares