N-acetylneuraminic acid coupled human recombinant TNFα exhibits enhanced anti-tumor activity against Meth-A fibrosarcoma and reduced toxicity

In order to study the effect of glycosylation on its biological activities and to develop tumor necrosis factor α (TNFα) with less deleterious effects, N-acetylneuraminic acid (NeuAc) with a C9 spacer was chemically coupled to human recombinant TNFα. NeuAc-coupled TNFα (NeuAc-TNFα) exhibited reduced...

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Detalles Bibliográficos
Autores principales: Hayashi, Akiko, Hayashi, Hidetoshi, Chiba, Taku, Sasayama, Satoshi, Onozaki, Kikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2006
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080163/
https://www.ncbi.nlm.nih.gov/pubmed/17031641
http://dx.doi.org/10.1007/s00262-006-0210-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080163/
https://www.ncbi.nlm.nih.gov/pubmed/17031641
http://dx.doi.org/10.1007/s00262-006-0210-2

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