Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency

Common fragile sites (CFSs) are breakage-prone genomic loci, and are considered to be hotspots for genomic rearrangements frequently observed in cancers. Understanding the underlying mechanisms for CFS instability will lead to better insight on cancer etiology. Here we show that Polycomb group prote...

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Detalles Bibliográficos
Autores principales: Sanchez, Anthony, de Vivo, Angelo, Tonzi, Peter, Kim, Jeonghyeon, Huang, Tony T., Kee, Younghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080270/
https://www.ncbi.nlm.nih.gov/pubmed/32142505
http://dx.doi.org/10.1371/journal.pgen.1008524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080270/
https://www.ncbi.nlm.nih.gov/pubmed/32142505
http://dx.doi.org/10.1371/journal.pgen.1008524

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