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Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency
Common fragile sites (CFSs) are breakage-prone genomic loci, and are considered to be hotspots for genomic rearrangements frequently observed in cancers. Understanding the underlying mechanisms for CFS instability will lead to better insight on cancer etiology. Here we show that Polycomb group prote...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080270/ https://www.ncbi.nlm.nih.gov/pubmed/32142505 http://dx.doi.org/10.1371/journal.pgen.1008524 |