The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing protocol. We observe most TCR sequences only...

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Detalles Bibliográficos
Autores principales: de Greef, Peter C, Oakes, Theres, Gerritsen, Bram, Ismail, Mazlina, Heather, James M, Hermsen, Rutger, Chain, Benjamin, de Boer, Rob J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080410/
https://www.ncbi.nlm.nih.gov/pubmed/32187010
http://dx.doi.org/10.7554/eLife.49900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080410/
https://www.ncbi.nlm.nih.gov/pubmed/32187010
http://dx.doi.org/10.7554/eLife.49900

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