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The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing protocol. We observe most TCR sequences only...

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Detalles Bibliográficos
Autores principales:	de Greef, Peter C, Oakes, Theres, Gerritsen, Bram, Ismail, Mazlina, Heather, James M, Hermsen, Rutger, Chain, Benjamin, de Boer, Rob J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080410/ https://www.ncbi.nlm.nih.gov/pubmed/32187010 http://dx.doi.org/10.7554/eLife.49900

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