Cargando…

The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing protocol. We observe most TCR sequences only...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Greef, Peter C, Oakes, Theres, Gerritsen, Bram, Ismail, Mazlina, Heather, James M, Hermsen, Rutger, Chain, Benjamin, de Boer, Rob J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080410/ https://www.ncbi.nlm.nih.gov/pubmed/32187010 http://dx.doi.org/10.7554/eLife.49900

Ejemplares similares

High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities
por: Heather, James M, et al.
Publicado: (2017)

Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical, and Versatile
por: Oakes, Theres, et al.
Publicado: (2017)

The T Cell Response to the Contact Sensitizer Paraphenylenediamine Is Characterized by a Polyclonal Diverse Repertoire of Antigen-Specific Receptors
por: Oakes, Theres, et al.
Publicado: (2017)

RTCR: a pipeline for complete and accurate recovery of T cell repertoires from high throughput sequencing data
por: Gerritsen, Bram, et al.
Publicado: (2016)

Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis
por: Adamska, Julia Z, et al.
Publicado: (2023)

Repeated outbreaks drive the evolution of bacteriophage communication
por: Doekes, Hilje M, et al.
Publicado: (2021)

Broadly reactive human CD4(+) T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire
por: Cassotta, Antonino, et al.
Publicado: (2020)

Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy
por: Heather, James M., et al.
Publicado: (2016)

Identical sequences found in distant genomes reveal frequent horizontal transfer across the bacterial domain
por: Sheinman, Michael, et al.
Publicado: (2021)

Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation
por: Ayoglu, Burcu, et al.
Publicado: (2023)

Toxin production spontaneously becomes regulated by local cell density in evolving bacterial populations
por: Doekes, Hilje M., et al.
Publicado: (2019)

A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data
por: Nouri, Nima, et al.
Publicado: (2018)

Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution
por: Bonarius, Hendrik P.J., et al.
Publicado: (2006)

Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires
por: Goffinet, Jack, et al.
Publicado: (2021)

Early life imprints the hierarchy of T cell clone sizes
por: Gaimann, Mario U, et al.
Publicado: (2020)

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities
por: Wink, Steven, et al.
Publicado: (2016)

BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression
por: NandyMazumdar, Monali, et al.
Publicado: (2021)

Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation
por: Gkazi, Athina Soragia, et al.
Publicado: (2018)

Towards a unified model of naive T cell dynamics across the lifespan
por: Rane, Sanket, et al.
Publicado: (2022)

Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness
por: Panda, Rajanikant, et al.
Publicado: (2022)

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
por: Ovchinnikov, Victor, et al.
Publicado: (2018)

T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences
por: Madi, Asaf, et al.
Publicado: (2017)

Computational analysis of stochastic heterogeneity in PCR amplification efficiency revealed by single molecule barcoding
por: Best, Katharine, et al.
Publicado: (2015)

Correlated evolution between repertoire size and song plasticity predicts that sexual selection on song promotes open-ended learning
por: Robinson, Cristina M, et al.
Publicado: (2019)

The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling
por: Smirnova, Anastasia O, et al.
Publicado: (2023)

Broad functional profiling of fission yeast proteins using phenomics and machine learning
por: Rodríguez-López, María, et al.
Publicado: (2023)

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging
por: Egorov, Evgeny S., et al.
Publicado: (2018)

Guinea pig immunoglobulin VH and VL naïve repertoire analysis
por: Matsuzawa, Shun, et al.
Publicado: (2018)

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection
por: Minervina, Anastasia A, et al.
Publicado: (2021)

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones
por: Minervina, Anastasia A, et al.
Publicado: (2020)

Alignment free identification of clones in B cell receptor repertoires
por: Lindenbaum, Ofir, et al.
Publicado: (2020)

Virus Encoded MHC-Like Decoys Diversify the Inhibitory KIR Repertoire
por: Carrillo-Bustamante, Paola, et al.
Publicado: (2013)

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels
por: Gossel, Graeme, et al.
Publicado: (2017)

Charge-driven condensation of RNA and proteins suggests broad role of phase separation in cytoplasmic environments
por: Dutagaci, Bercem, et al.
Publicado: (2021)

cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non‐Hodgkin orbital lymphoma and idiopathic orbital inflammation
por: Laban, Kamil G., et al.
Publicado: (2020)

PKS 0208-512 detected at MeV energies by COMPTEL: a new "MeV-Blazar" candidate
por: Blom, J J, et al.
Publicado: (1995)

Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
por: Cinelli, Mattia, et al.
Publicado: (2017)

Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice
por: Xian, Feng, et al.
Publicado: (2022)

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8(+) T-Cell Receptor Repertoire of Extremely Preterm Neonates
por: Carey, Alison J., et al.
Publicado: (2017)

Positive and negative selection shape the human naive B cell repertoire
por: Chen, Jeff W., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9trie6rfo0lm95qiq2blvrac9g