Cargando…

P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis

INTRODUCTION: Clearance of damaged cells and debris is beneficial for the functional recovery after ischemic brain injury. However, the specific phagocytic receptor that mediates microglial phagocytosis after ischemic stroke is unknown. AIM: To investigate whether P2Y6 receptor‐mediated microglial p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Ruo‐Xue, Shen, Hui, Huang, Shu‐Xian, Wang, Li‐Ping, Li, Zong‐Wei, Peng, Peng, Mamtilahun, Muyassar, Tang, Yao‐Hui, Shen, Fan‐Xia, Tian, Heng‐Li, Yang, Guo‐Yuan, Zhang, Zhi‐Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080436/ https://www.ncbi.nlm.nih.gov/pubmed/32154670 http://dx.doi.org/10.1111/cns.13296

Ejemplares similares

The Role of Microglial Phagocytosis in Ischemic Stroke
por: Jia, Junqiu, et al.
Publicado: (2022)

TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model
por: Zhang, Yijie, et al.
Publicado: (2020)

Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia
por: Cao, Qian, et al.
Publicado: (2023)

Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke
por: Yang, Jin, et al.
Publicado: (2021)

DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
por: Mamtilahun, Muyassar, et al.
Publicado: (2021)

Reticulocalbin-1 Facilitates Microglial Phagocytosis
por: Ding, Ying, et al.
Publicado: (2015)

Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice
por: Shan, Hui-Min, et al.
Publicado: (2020)

BK Channel-Mediated Microglial Phagocytosis Alleviates Neurological Deficit After Ischemic Stroke
por: Huang, Shuxian, et al.
Publicado: (2021)

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
por: Zhang, Can, et al.
Publicado: (2018)

Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury
por: Shen, Hui, et al.
Publicado: (2022)

Erythropoietin Enhances Post-ischemic Migration and Phagocytosis and Alleviates the Activation of Inflammasomes in Human Microglial Cells
por: Arik, Eren, et al.
Publicado: (2022)

Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens
por: Chen, Xin-hai, et al.
Publicado: (2017)

Central nervous system diseases related to pathological microglial phagocytosis
por: Wang, Ke, et al.
Publicado: (2021)

Qki is an essential regulator of microglial phagocytosis in demyelination
por: Ren, Jiangong, et al.
Publicado: (2020)

Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice
por: Deng, Li-Dong, et al.
Publicado: (2022)

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
por: Abiega, Oihane, et al.
Publicado: (2016)

Chronic Exposure to Subtherapeutic Antibiotics Aggravates Ischemic Stroke Outcome in Mice
por: Dong, Xiao-Hui, et al.
Publicado: (2017)

Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke
por: Deng, Yiming, et al.
Publicado: (2019)

Propofol suppresses microglial phagocytosis through the downregulation of MFG-E8
por: Cai, Xiaoying, et al.
Publicado: (2021)

Continued P2X7 activation leads to mitochondrial fission and compromising microglial phagocytosis after subarachnoid haemorrhage
por: Tao, Tao, et al.
Publicado: (2022)

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
por: Abiega, Oihane, et al.
Publicado: (2016)

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
por: Abiega, Oihane, et al.
Publicado: (2016)

Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury
por: Zhou, Zhi-Lai, et al.
Publicado: (2022)

Promotion of microglial phagocytosis by tuftsin stimulates remyelination in experimental autoimmune encephalomyelitis
por: Bao, Zheng, et al.
Publicado: (2019)

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
por: Lin, Geng, et al.
Publicado: (2020)

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
por: Konishi, Hiroyuki, et al.
Publicado: (2020)

Interrogation of human microglial phagocytosis by CRISPR genome editing
por: Chang, Jason Cheng-Yu, et al.
Publicado: (2023)

Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury
por: Xue, Tengfei, et al.
Publicado: (2022)

Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke
por: Zhou, Feihui, et al.
Publicado: (2020)

Pharmacological Targeting of CSF1R Inhibits Microglial Proliferation and Aggravates the Progression of Cerebral Ischemic Pathology
por: Hou, Boru, et al.
Publicado: (2020)

Commentary: CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
por: Wei, Penghui, et al.
Publicado: (2019)

M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice
por: Li, Zongwei, et al.
Publicado: (2021)

Promotion of microglial phagocytosis by tuftsin stimulates remyelination inexperimental autoimmune en- cephalomyelitis
por: Bao, Zheng, et al.
Publicado: (2020)

Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer’s disease
por: Fairley, Lauren H., et al.
Publicado: (2023)

Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
por: Zhou, Tian, et al.
Publicado: (2022)

CD22 blockade restores homeostatic microglial phagocytosis in aging brains
por: Pluvinage, John V., et al.
Publicado: (2019)

Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration
por: Hu, Guoku, et al.
Publicado: (2018)

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2020)

Sweepers in the CNS: Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis
por: Noda, Mariko, et al.
Publicado: (2012)

MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons
por: Fuller, Abby D., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_hiqit6q49ipa13pq62l4t8gd0f