Amino-acid selective isotope labeling enables simultaneous overlapping signal decomposition and information extraction from NMR spectra

Signal overlapping is a major bottleneck for protein NMR analysis. We propose a new method, stable-isotope-assisted parameter extraction (SiPex), to resolve overlapping signals by a combination of amino-acid selective isotope labeling (AASIL) and tensor decomposition. The basic idea of Sipex is that...

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Detalles Bibliográficos
Autores principales: Kasai, Takuma, Ono, Shunsuke, Koshiba, Seizo, Yamamoto, Masayuki, Tanaka, Toshiyuki, Ikeda, Shiro, Kigawa, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080692/
https://www.ncbi.nlm.nih.gov/pubmed/32002710
http://dx.doi.org/10.1007/s10858-019-00295-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080692/
https://www.ncbi.nlm.nih.gov/pubmed/32002710
http://dx.doi.org/10.1007/s10858-019-00295-9

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