Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

A number of recent papers report that standing genetic variation in natural populations includes ubiquitous polymorphisms within target sites for Cas9-based gene drive (CGD) and that these “drive resistant alleles” (DRA) preclude the successful application of CGD for managing these populations. Here...

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Detalles Bibliográficos
Autores principales: Schmidt, Hanno, Collier, Travis C., Hanemaaijer, Mark J., Houston, Parker D., Lee, Yoosook, Lanzaro, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080748/
https://www.ncbi.nlm.nih.gov/pubmed/32188851
http://dx.doi.org/10.1038/s41467-020-15204-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080748/
https://www.ncbi.nlm.nih.gov/pubmed/32188851
http://dx.doi.org/10.1038/s41467-020-15204-0

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