Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes

Retinoic acid has been previously proposed in the treatment of Alzheimer’s disease (AD). Here, five transgenic mouse models expressing AD and frontotemporal dementia risk genes (i.e., PLB2(APP), PLB2(TAU), PLB1(Double), PLB1(Triple), and PLB4) were used to investigate if consistent alterations exist...

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Detalles Bibliográficos
Autores principales: Khatib, Thabat, Chisholm, David R., Whiting, Andrew, Platt, Bettina, McCaffery, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081102/
https://www.ncbi.nlm.nih.gov/pubmed/31884477
http://dx.doi.org/10.3233/JAD-190931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081102/
https://www.ncbi.nlm.nih.gov/pubmed/31884477
http://dx.doi.org/10.3233/JAD-190931

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