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Zibotentan, an Endothelin A Receptor Antagonist, Prevents Amyloid-β-Induced Hypertension and Maintains Cerebral Perfusion

Cerebral blood flow is reduced in Alzheimer’s disease (AD), which is associated with mid-life hypertension. In people with increased cerebral vascular resistance due to vertebral artery or posterior communicating artery hypoplasia, there is evidence that hypertension develops as a protective mechani...

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Detalles Bibliográficos
Autores principales: Palmer, Jennifer C., Tayler, Hannah M., Dyer, Laurence, Kehoe, Patrick G., Paton, Julian F.R., Love, Seth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081103/
https://www.ncbi.nlm.nih.gov/pubmed/31903990
http://dx.doi.org/10.3233/JAD-190630