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Why does the Aβ peptide of Alzheimer share structural similarity with antimicrobial peptides?

The Aβ peptides causally associated with Alzheimer disease have been seen as seemingly purposeless species produced by intramembrane cleavage under both physiological and pathological conditions. However, it has been increasingly suggested that they could instead constitute an ancient, highly conser...

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Detalles Bibliográficos
Autores principales: Pastore, Annalisa, Raimondi, Francesco, Rajendran, Lawrence, Temussi, Piero Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081199/
https://www.ncbi.nlm.nih.gov/pubmed/32193491
http://dx.doi.org/10.1038/s42003-020-0865-9