Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Resistance development to one chemotherapeutic reagent leads frequently to acquired tolerance to other compounds, limiting the therapeutic options for cancer treatment. Herein, we find that overexpression of Rac1 is associated with multi-drug resistance to the neoadjuvant chemotherapy (NAC). Mechani...

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Detalles Bibliográficos
Autores principales: Li, Qingjian, Qin, Tao, Bi, Zhuofei, Hong, Huangming, Ding, Lin, Chen, Jiewen, Wu, Wei, Lin, Xiaorong, Fu, Wenkui, Zheng, Fang, Yao, Yandan, Luo, Man-Li, Saw, Phei Er, Wulf, Gerburg M., Xu, Xiaoding, Song, Erwei, Yao, Herui, Hu, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081201/
https://www.ncbi.nlm.nih.gov/pubmed/32193458
http://dx.doi.org/10.1038/s41467-020-15308-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081201/
https://www.ncbi.nlm.nih.gov/pubmed/32193458
http://dx.doi.org/10.1038/s41467-020-15308-7

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