Cargando…

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Resistance development to one chemotherapeutic reagent leads frequently to acquired tolerance to other compounds, limiting the therapeutic options for cancer treatment. Herein, we find that overexpression of Rac1 is associated with multi-drug resistance to the neoadjuvant chemotherapy (NAC). Mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qingjian, Qin, Tao, Bi, Zhuofei, Hong, Huangming, Ding, Lin, Chen, Jiewen, Wu, Wei, Lin, Xiaorong, Fu, Wenkui, Zheng, Fang, Yao, Yandan, Luo, Man-Li, Saw, Phei Er, Wulf, Gerburg M., Xu, Xiaoding, Song, Erwei, Yao, Herui, Hu, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081201/ https://www.ncbi.nlm.nih.gov/pubmed/32193458 http://dx.doi.org/10.1038/s41467-020-15308-7

Ejemplares similares

A Robust Nanoparticle Platform for RNA Interference in Macrophages to Suppress Tumor Cell Migration
por: Liang, Shi, et al.
Publicado: (2018)

Fully Natural Lecithin Encapsulated Nano-Resveratrol for Anti-Cancer Therapy
por: Liang, Meiyi, et al.
Publicado: (2022)

LncRNA Uc003xsl.1-Mediated Activation of the NFκB/IL8 Axis Promotes Progression of Triple-Negative Breast Cancer
por: Xu, Ying, et al.
Publicado: (2022)

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
por: Milanese, Chiara, et al.
Publicado: (2020)

Nanoparticles (NPs)‐Meditated LncRNA AFAP1‐AS1 Silencing to Block Wnt/β‐Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy
por: Bi, Zhuofei, et al.
Publicado: (2020)

ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway
por: Yin, Xin, et al.
Publicado: (2017)

Markers of Tumor-Initiating Cells Predict Chemoresistance in Breast Cancer
por: Gong, Chang, et al.
Publicado: (2010)

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
por: Zheng, Fang, et al.
Publicado: (2021)

Regulation of the pentose phosphate pathway in cancer
por: Jiang, Peng, et al.
Publicado: (2014)

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020)

Nanocarrier-mediated antioxidant delivery for liver diseases
por: Li, Senlin, et al.
Publicado: (2020)

Elevated pentose phosphate pathway is involved in the recovery of hypoxia-induced erythrocytosis
por: Liu, Chang, et al.
Publicado: (2017)

The Pentose Phosphate Pathway Regulates the Circadian Clock
por: Rey, Guillaume, et al.
Publicado: (2016)

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
por: Ge, Tongxin, et al.
Publicado: (2020)

Queueing theory model of pentose phosphate pathway
por: Kloska, Sylwester M., et al.
Publicado: (2022)

Pentose Phosphate Pathway Reactions in Photosynthesizing Cells
por: Sharkey, Thomas D.
Publicado: (2021)

The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity
por: Lin, Jinguan, et al.
Publicado: (2022)

Tumor-Associated Fibronectin Targeted Liposomal Nanoplatform for Cyclophilin A siRNA Delivery and Targeted Malignant Glioblastoma Therapy
por: Saw, Phei Er, et al.
Publicado: (2018)

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
por: Stincone, Anna, et al.
Publicado: (2014)

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
por: Kowalik, Marta Anna, et al.
Publicado: (2017)

The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance
por: Giacomini, Isabella, et al.
Publicado: (2020)

Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation
por: Wei, Chunfang, et al.
Publicado: (2023)

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
por: Cho, Eunae Sandra, et al.
Publicado: (2018)

Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
por: Choi, Junjeong, et al.
Publicado: (2018)

Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose
por: Chomvong, Kulika, et al.
Publicado: (2016)

The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
por: Tu, Dezhen, et al.
Publicado: (2019)

Two high-rate pentose-phosphate pathways in cancer cells
por: Cossu, Vanessa, et al.
Publicado: (2020)

Elevated pentose phosphate pathway flux supports appendage regeneration
por: Patel, Jeet H., et al.
Publicado: (2022)

Impact of the pentose phosphate pathway on metabolism and pathogenesis of Staphylococcus aureus
por: Kim, Jisun, et al.
Publicado: (2023)

Multiple Independent Fusions of Glucose-6-Phosphate Dehydrogenase with Enzymes in the Pentose Phosphate Pathway
por: Stover, Nicholas A., et al.
Publicado: (2011)

Differently Charged Super-Paramagnetic Iron Oxide Nanoparticles Preferentially Induced M1-Like Phenotype of Macrophages
por: Zhang, Wenyue, et al.
Publicado: (2020)

Astroglial pentose phosphate pathway rates in response to high-glucose environments
por: Takahashi, Shinichi, et al.
Publicado: (2012)

TAp73 enhances the pentose phosphate pathway and supports cell proliferation
por: Du, Wenjing, et al.
Publicado: (2013)

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei
por: Kerkhoven, Eduard J., et al.
Publicado: (2013)

Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
por: Peiró, Concepción, et al.
Publicado: (2016)

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
por: Ahmad, F, et al.
Publicado: (2016)

Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway
por: Almeida, Ana S., et al.
Publicado: (2018)

The plastidial pentose phosphate pathway is essential for postglobular embryo development in Arabidopsis
por: Andriotis, Vasilios M. E., et al.
Publicado: (2019)

6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway
por: Li, Changzheng, et al.
Publicado: (2021)

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy
por: Bojkova, Denisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gpn3317ti3gptu6i8tadhkubsu