A severe leakage of intermediates to shunt products in acarbose biosynthesis

The α-glucosidase inhibitor acarbose, produced by Actinoplanes sp. SE50/110, is a well-known drug for the treatment of type 2 diabetes mellitus. However, the largely unexplored biosynthetic mechanism of this compound has impeded further titer improvement. Herein, we uncover that 1-epi-valienol and v...

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Detalles Bibliográficos
Autores principales: Zhao, Qinqin, Luo, Yuchang, Zhang, Xin, Kang, Qianjin, Zhang, Dan, Zhang, Lili, Bai, Linquan, Deng, Zixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081202/
https://www.ncbi.nlm.nih.gov/pubmed/32193369
http://dx.doi.org/10.1038/s41467-020-15234-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081202/
https://www.ncbi.nlm.nih.gov/pubmed/32193369
http://dx.doi.org/10.1038/s41467-020-15234-8

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