Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors

[Image: see text] Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can tri...

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Autores principales: Eksteen, J. Johannes, Ausbacher, Dominik, Vasskog, Terje, Rekdal, Øystein, Svendsen, John S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081261/
https://www.ncbi.nlm.nih.gov/pubmed/32201779
http://dx.doi.org/10.1021/acsomega.9b00700
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author Eksteen, J. Johannes
Ausbacher, Dominik
Vasskog, Terje
Rekdal, Øystein
Svendsen, John S. M.
author_facet Eksteen, J. Johannes
Ausbacher, Dominik
Vasskog, Terje
Rekdal, Øystein
Svendsen, John S. M.
author_sort Eksteen, J. Johannes
collection PubMed
description [Image: see text] Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown.
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spelling pubmed-70812612020-03-20 Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors Eksteen, J. Johannes Ausbacher, Dominik Vasskog, Terje Rekdal, Øystein Svendsen, John S. M. ACS Omega [Image: see text] Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown. American Chemical Society 2020-03-06 /pmc/articles/PMC7081261/ /pubmed/32201779 http://dx.doi.org/10.1021/acsomega.9b00700 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Eksteen, J. Johannes
Ausbacher, Dominik
Vasskog, Terje
Rekdal, Øystein
Svendsen, John S. M.
Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
title Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
title_full Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
title_fullStr Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
title_full_unstemmed Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
title_short Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
title_sort selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081261/
https://www.ncbi.nlm.nih.gov/pubmed/32201779
http://dx.doi.org/10.1021/acsomega.9b00700
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