Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

T cells play a critical role in controlling viral infection; however, the mechanisms regulating their responses remain incompletely understood. Here, we investigated the role of topoisomerase IIA (Top2α, an enzyme that is essential in resolving entangled DNA strands during replication) in telomeric...

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Detalles Bibliográficos
Autores principales: Dang, Xindi, Ogbu, Stella C., Zhao, Juan, Nguyen, Lam Ngoc Thao, Cao, Dechao, Nguyen, Lam Nhat, Khanal, Sushant, Schank, Madison, Thakuri, Bal Krishna Chand, Wu, Xiao Y., Morrison, Zheng D., Zhang, Jinyu, Li, Zhengke, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Wang, Zhengqiang, Moorman, Jonathan P., Yao, Zhi Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081277/
https://www.ncbi.nlm.nih.gov/pubmed/32193368
http://dx.doi.org/10.1038/s41419-020-2395-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081277/
https://www.ncbi.nlm.nih.gov/pubmed/32193368
http://dx.doi.org/10.1038/s41419-020-2395-2

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