Ca(2+)-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids

The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug-resistant enterococci. Its precise mechanism of action is incompletely understood, and a specific molecular target has not...

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Detalles Bibliográficos
Autores principales: Grein, Fabian, Müller, Anna, Scherer, Katharina M., Liu, Xinliang, Ludwig, Kevin C., Klöckner, Anna, Strach, Manuel, Sahl, Hans-Georg, Kubitscheck, Ulrich, Schneider, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081307/
https://www.ncbi.nlm.nih.gov/pubmed/32193379
http://dx.doi.org/10.1038/s41467-020-15257-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081307/
https://www.ncbi.nlm.nih.gov/pubmed/32193379
http://dx.doi.org/10.1038/s41467-020-15257-1

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