YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

The Hippo TEAD-transcriptional regulators YAP1 and TAZ are central for cell renewal and cancer growth; however, the specific downstream gene networks involved in their activity are not completely understood. Here we introduce TEADi, a genetically encoded inhibitor of the interaction of YAP1 and TAZ...

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Detalles Bibliográficos
Autores principales: Yuan, Yao, Park, Jeannie, Feng, Amber, Awasthi, Parirokh, Wang, Zhiyong, Chen, Qianming, Iglesias-Bartolome, Ramiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081327/
https://www.ncbi.nlm.nih.gov/pubmed/32193376
http://dx.doi.org/10.1038/s41467-020-15301-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081327/
https://www.ncbi.nlm.nih.gov/pubmed/32193376
http://dx.doi.org/10.1038/s41467-020-15301-0

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