Cargando…

YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

The Hippo TEAD-transcriptional regulators YAP1 and TAZ are central for cell renewal and cancer growth; however, the specific downstream gene networks involved in their activity are not completely understood. Here we introduce TEADi, a genetically encoded inhibitor of the interaction of YAP1 and TAZ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Yao, Park, Jeannie, Feng, Amber, Awasthi, Parirokh, Wang, Zhiyong, Chen, Qianming, Iglesias-Bartolome, Ramiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081327/ https://www.ncbi.nlm.nih.gov/pubmed/32193376 http://dx.doi.org/10.1038/s41467-020-15301-0

Ejemplares similares

A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy
por: Pobbati, Ajaybabu V., et al.
Publicado: (2020)

FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling
por: Knyazeva, Anastasia, et al.
Publicado: (2020)

Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex
por: Pobbati, Ajaybabu V., et al.
Publicado: (2020)

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
por: Cunningham, Richard, et al.
Publicado: (2022)

Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors
por: Nouri, Kazem, et al.
Publicado: (2019)

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex
por: Kaan, Hung Yi Kristal, et al.
Publicado: (2017)

Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma
por: Pulito, Claudio, et al.
Publicado: (2019)

The Telluride YAP/TAZ and TEAD Workshop: A Small Meeting with a Big Impact
por: Weinberg, Guy L., et al.
Publicado: (2023)

Integrin signalling regulates YAP and TAZ to control skin homeostasis
por: Elbediwy, Ahmed, et al.
Publicado: (2016)

Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis
por: Hicks-Berthet, Julia, et al.
Publicado: (2021)

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
por: Ong, Yu Ting, et al.
Publicado: (2022)

Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
por: Ning, Boting, et al.
Publicado: (2023)

The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment
por: Mokhtari, Reza Bayat, et al.
Publicado: (2023)

Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development
por: Astone, Matteo, et al.
Publicado: (2018)

Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches
por: Kaan, Hung Yi Kristal, et al.
Publicado: (2017)

TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish
por: Fillatre, Jonathan, et al.
Publicado: (2019)

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma
por: Laraba, Liyam, et al.
Publicado: (2022)

YAP/TAZ initiate and maintain Schwann cell myelination
por: Grove, Matthew, et al.
Publicado: (2017)

Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells
por: El Yousfi, Younes, et al.
Publicado: (2023)

Gatekeepers of pancreas: TEAD and YAP
por: Rodríguez-Seguí, Santiago A., et al.
Publicado: (2015)

Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression
por: Cai, Xiaomin, et al.
Publicado: (2021)

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis
por: Zinatizadeh, Mohammad Reza, et al.
Publicado: (2019)

Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz
por: Jones, Dakota L., et al.
Publicado: (2023)

Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells
por: Van Sciver, Nicholas, et al.
Publicado: (2021)

Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway
por: Liu, Haitao, et al.
Publicado: (2022)

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
por: Hagenbeek, Thijs J., et al.
Publicado: (2023)

Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells
por: Sun, Yang, et al.
Publicado: (2022)

Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells
por: Gao, Yang, et al.
Publicado: (2014)

Repurposing of Drugs Targeting YAP-TEAD Functions
por: Elisi, Gian Marco, et al.
Publicado: (2018)

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex
por: Che, Kepeng, et al.
Publicado: (2022)

The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin
por: Rognoni, Emanuel, et al.
Publicado: (2019)

Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation
por: Canu, Valeria, et al.
Publicado: (2020)

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
por: Moroishi, Toshiro, et al.
Publicado: (2015)

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface
por: Gibault, Floriane, et al.
Publicado: (2018)

Multifaceted function of YAP/TEAD on chromatin:prospects of ‘A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer’
por: Chen, Lizhen, et al.
Publicado: (2019)

DNA binding partners of YAP/TAZ
por: Kim, Min-Kyu, et al.
Publicado: (2018)

Hippo-YAP/TAZ signaling in angiogenesis
por: Park, Jeong Ae, et al.
Publicado: (2018)

YAP and TAZ regulate cell volume
por: Perez-Gonzalez, Nicolas A., et al.
Publicado: (2019)

Mechanisms of YAP/TAZ transcriptional control
por: Battilana, Giusy, et al.
Publicado: (2021)

YAP/TAZ in Bone and Cartilage Biology
por: Zarka, Mylène, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iqeuh8sk3rr8bg3oq2lqmdu1mb