Cargando…

Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

BACKGROUND: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin caused by either the integration of Merkel cell polyomavirus (MCPyV) and expression of viral T antigens or by ultraviolet-induced damage to the tumor genome from excessive sunlight exposure. An increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Starrett, Gabriel J., Thakuria, Manisha, Chen, Tianqi, Marcelus, Christina, Cheng, Jingwei, Nomburg, Jason, Thorner, Aaron R., Slevin, Michael K., Powers, Winslow, Burns, Robert T., Perry, Caitlin, Piris, Adriano, Kuo, Frank C., Rabinowits, Guilherme, Giobbie-Hurder, Anita, MacConaill, Laura E., DeCaprio, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081548/ https://www.ncbi.nlm.nih.gov/pubmed/32188490 http://dx.doi.org/10.1186/s13073-020-00727-4

Ejemplares similares

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma
por: Starrett, Gabriel J., et al.
Publicado: (2017)

YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma
por: Frost, Thomas C., et al.
Publicado: (2023)

Predictors of immunotherapy benefit in Merkel cell carcinoma
por: Kacew, Alec J., et al.
Publicado: (2020)

Association of Programmed Death 1 Protein Ligand (PD-L1) Expression With Prognosis in Merkel Cell Carcinoma
por: Hanna, Glenn J., et al.
Publicado: (2020)

Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2
por: Nomburg, Jason, et al.
Publicado: (2020)

The Merkel Cell Polyomavirus T Antigens Function as Tumor Promoters in Murine Skin
por: Spurgeon, Megan E., et al.
Publicado: (2021)

Merkel Cell Polyomavirus: Oncogenesis in a Stable Genome
por: Ahmed, Mona M., et al.
Publicado: (2021)

Does a new polyomavirus contribute to Merkel cell carcinoma?
por: Garneski, Kelly M, et al.
Publicado: (2008)

Is this the end of cytotoxic chemotherapy in Merkel cell carcinoma?
por: Rabinowits, Guilherme
Publicado: (2017)

Systemic Therapy for Merkel Cell Carcinoma: What’s on the Horizon?
por: Rabinowits, Guilherme
Publicado: (2014)

Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses
por: Nomburg, Jason, et al.
Publicado: (2022)

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development
por: Spurgeon, Megan E., et al.
Publicado: (2022)

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma
por: Lee, Patrick C., et al.
Publicado: (2022)

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation
por: Berrios, Christian, et al.
Publicado: (2016)

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities
por: Harms, Paul W., et al.
Publicado: (2018)

Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing
por: MacConaill, Laura E., et al.
Publicado: (2018)

Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma
por: Yang, Jiawen, et al.
Publicado: (2023)

Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma
por: Ananthapadmanabhan, Varsha, et al.
Publicado: (2022)

Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment
por: Morimoto, Yoshihiro, et al.
Publicado: (2022)

An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response
por: Knepper, Todd C., et al.
Publicado: (2021)

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis
por: Park, Donglim Esther, et al.
Publicado: (2020)

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis
por: Cheng, Jingwei, et al.
Publicado: (2017)

Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses
por: Dowlatshahi, Mitra, et al.
Publicado: (2013)

Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes
por: Loyo, M, et al.
Publicado: (2012)

CRISPR–Cas9 Genetic Analysis of Virus–Host Interactions
por: Gebre, Makda, et al.
Publicado: (2018)

Elevated levels of Merkel cell polyoma virus in the anophthalmic conjunctiva
por: Siegal, Nora, et al.
Publicado: (2021)

Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome
por: Nishino, Mizuki, et al.
Publicado: (2014)

Toward accurate high-throughput SNP genotyping in the presence of inherited copy number variation
por: MacConaill, Laura E, et al.
Publicado: (2007)

Tertiary Lymphoid Structures and Chemokine Landscape in Virus-Positive and Virus-Negative Merkel Cell Carcinoma
por: Nakamura, Motoki, et al.
Publicado: (2022)

The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment
por: Mendoza, María-Dolores, et al.
Publicado: (2020)

Characterization of Self-Assembled Virus-Like Particles of Merkel Cell Polyomavirus
por: Li, Tian-Cheng, et al.
Publicado: (2015)

Endometrial cancer with an EML4-ALK rearrangement
por: Craig, Jeffrey W., et al.
Publicado: (2018)

Mucosal inflammation predicts response to systemic steroids in immune checkpoint inhibitor colitis
por: Mooradian, Meghan J, et al.
Publicado: (2020)

The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma
por: Wu, Xinqi, et al.
Publicado: (2012)

Real-world outcomes treating patients with advanced cutaneous squamous cell carcinoma with immune checkpoint inhibitors (CPI)
por: Hanna, Glenn J., et al.
Publicado: (2020)

Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma
por: Sarma, Bhavishya, et al.
Publicado: (2020)

Merkel Cell Polyomavirus and Merkel Cell Carcinoma
por: Pietropaolo, Valeria, et al.
Publicado: (2020)

DETECTing Merkel Cell Polyomavirus in Merkel Tumors
por: Arora, Reety, et al.
Publicado: (2020)

Interpreting breast international group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer
por: Regan, Meredith M, et al.
Publicado: (2011)

Reducing the carbon footprint of research: experience from the NightLife study
por: Quann, Niamh, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6d08eqk1lkltt2f79tmt2i3h9k