Cargando…

Overexpression of Karyopherin Subunit alpha 2 (KPNA2) Predicts Unfavorable Prognosis and Promotes Bladder Cancer Tumorigenicity via the P53 Pathway

BACKGROUND: We sought to investigate the expression of KPNA2 in bladder cancer (BC) and its relationship with prognosis, and to analyze the potential mechanism of KPNA2 in promoting BC progression. MATERIAL/METHODS: The RNA-seq data on BC from The Cancer Genome Atlas (TCGA) database were imported in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Changlong, Sun, Li, Liu, Shaozhuang, Zhang, Enchong, Song, Yongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2020
Materias:	Database Analysis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081662/ https://www.ncbi.nlm.nih.gov/pubmed/32147666 http://dx.doi.org/10.12659/MSM.921087

Ejemplares similares

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
por: Christiansen, Anders, et al.
Publicado: (2013)

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells
por: Vuorinen, Elisa M., et al.
Publicado: (2018)

Correction to: Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells
por: Vuorinen, Elisa M., et al.
Publicado: (2019)

Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis
por: Yang, Zhengqing, et al.
Publicado: (2021)

Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient Outcomes
por: Du, Xiaomei, et al.
Publicado: (2020)

Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer
por: Ohhara, Yoshihito, et al.
Publicado: (2022)

Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors
por: Kelley, Joshua B, et al.
Publicado: (2010)

Overexpression of Apolipoprotein C1 (APOC1) in Clear Cell Renal Cell Carcinoma and Its Prognostic Significance
por: Xiao, Huaying, et al.
Publicado: (2021)

Epithelial Splicing Regulatory Protein 1 Is Overexpressed in Breast Cancer and Predicts Poor Prognosis for Breast Cancer Patients
por: Liu, Xinyu, et al.
Publicado: (2021)

Clinical Course of 53 Previously Vaccinated Patients Admitted to the National Hospital in Warsaw, Poland with COVID-19 Between November 2021 and March 2022
por: Zaczyński, Artur, et al.
Publicado: (2023)

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation
por: Laitman, Benjamin M., et al.
Publicado: (2017)

Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer
por: Feng, Yanyan, et al.
Publicado: (2020)

Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as Prognosis Markers of Overall Survival in Gastric Cancer
por: Shan, Zexing, et al.
Publicado: (2021)

Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma
por: Zhao, Xuemiao, et al.
Publicado: (2021)

A Mechanism Underlying Sex-Associated Differences in Ankylosing Spondylitis: Troponin C2, Fast Skeletal Type (TNNC2) and Calcium Signaling Pathway
por: Yu, Chaojie, et al.
Publicado: (2020)

H Long Terminal Repeat-Associating 2 (HHLA2) is a Biomarker of Advanced Stage Hepatocellular Carcinoma and Promotes Tumor Cell Development In Vitro
por: Luo, Min, et al.
Publicado: (2021)

H2A Histone Family Member Z (H2AFZ) Serves as a Prognostic Biomarker in Lung Adenocarcinoma: Bioinformatic Analysis and Experimental Validation
por: Li, Zongkuo, et al.
Publicado: (2022)

Long non-coding RNA HAGLROS facilitates tumorigenesis and progression in hepatocellular carcinoma by sponging miR-26b-5p to up-regulate karyopherin α2 (KPNA2) and inactivate p53 signaling
por: Tang, Gaofeng, et al.
Publicado: (2022)

Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus
por: Li, Chenxi, et al.
Publicado: (2020)

Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
por: Luo, Lin, et al.
Publicado: (2021)

Construction of Decision Trees Based on Gene Expression Omnibus Data to Classify Bladder Cancer and Its Subtypes
por: Zhou, Jia-Quan, et al.
Publicado: (2021)

Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma
por: He, Rong-Quan, et al.
Publicado: (2020)

Correlation Between High Expression of FOXA2 and Improved Overall Survival in Ovarian Cancer Patients
por: Shang, Hui, et al.
Publicado: (2021)

Relationship Between C-Reactive Protein and Respiratory Diseases in Patients with Type 2 Diabetic Retinopathy
por: Chen, Kejia, et al.
Publicado: (2022)

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma
por: Zou, Yiping, et al.
Publicado: (2020)

Prediction of MiR-21-5p in Promoting the Development of Lung Adenocarcinoma via PDZD2 Regulation
por: Cui, Shengjin, et al.
Publicado: (2020)

TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer
por: Zhou, Fang, et al.
Publicado: (2020)

Reinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Poland, April 2020 to July 2022
por: Morawiec, Emilia, et al.
Publicado: (2023)

Retrospective Study from a Single Center to Identify Risk Factors Associated with Reinfection in Patients Undergoing 2-Stage Revision Surgery for Periprosthetic Joint Infection
por: Zhang, Bingshi, et al.
Publicado: (2022)

Coexpression Analysis of the EZH2 Gene Using The Cancer Genome Atlas and Oncomine Databases Identifies Coexpressed Genes Involved in Biological Networks in Breast Cancer, Glioblastoma, and Prostate Cancer
por: Zhu, Jin, et al.
Publicado: (2020)

A Retrospective Population Study to Develop a Predictive Model of Prediabetes and Incident Type 2 Diabetes Mellitus from a Hospital Database in Japan Between 2004 and 2015
por: Wang, Hai, et al.
Publicado: (2020)

A Retrospective Population Study of 385 191 Positive Real-Time Reverse Transcription–Polymerase Chain Reaction Tests For SARS-CoV-2 from a Single Laboratory in Katowice, Poland from April 2020 to July 2022
por: Morawiec, Emilia, et al.
Publicado: (2023)

Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes
por: Umegaki-Arao, Noriko, et al.
Publicado: (2013)

Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer
por: Yu, Lei, et al.
Publicado: (2017)

Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling
por: Cui, Xiangrong, et al.
Publicado: (2021)

Overexpression of Karyopherin 2 in Human Ovarian Malignant Germ Cell Tumor Correlates with Poor Prognosis
por: He, Li, et al.
Publicado: (2012)

Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure
por: Huang, Dong-Hui, et al.
Publicado: (2016)

Karyopherins play the field
por: Leslie, Mitch
Publicado: (2006)

Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7
por: Duan, Jihui, et al.
Publicado: (2017)

Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7
por: Duan, Jihui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_07sq892agmg3oquf3pf9kapil2