Deletion of Btg1 Induces Prmt1-Dependent Apoptosis and Increased Stemness in Shh-Type Medulloblastoma Cells Without Affecting Tumor Frequency

About 30% of medulloblastomas (MBs), a tumor of the cerebellum, arise from cerebellar granule cell precursors (GCPs) undergoing transformation following activation of the Sonic hedgehog (Shh) pathway. To study this process, we generated a new MB model by crossing Patched1 heterozygous (Ptch1(+/−)) m...

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Detalles Bibliográficos
Autores principales: Ceccarelli, Manuela, D'Andrea, Giorgio, Micheli, Laura, Tirone, Felice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082329/
https://www.ncbi.nlm.nih.gov/pubmed/32231994
http://dx.doi.org/10.3389/fonc.2020.00226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082329/
https://www.ncbi.nlm.nih.gov/pubmed/32231994
http://dx.doi.org/10.3389/fonc.2020.00226

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