Cargando…

Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells

MicroRNAs (miRs) are one of the most important post-transcriptional repressors of gene expression. However, miR-574-5p has recently been shown to positively regulate the expression of microsomal prostaglandin E-synthase-1 (mPGES-1), a key enzyme in the prostaglandin E(2) (PGE(2)) biosynthesis, by ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Emmerich, Anne C., Wellstein, Julia, Ossipova, Elena, Baumann, Isabell, Lengqvist, Johan, Kultima, Kim, Jakobsson, Per-Johan, Steinhilber, Dieter, Saul, Meike J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082395/ https://www.ncbi.nlm.nih.gov/pubmed/32231562 http://dx.doi.org/10.3389/fphar.2020.00196

Ejemplares similares

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
por: Bergqvist, Filip, et al.
Publicado: (2019)

mPGES-1 and prostaglandin E(2): vital role in inflammation, hypoxic response, and survival
por: Siljehav, Veronica, et al.
Publicado: (2012)

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
por: Kirkby, Nicholas S, et al.
Publicado: (2019)

Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes
por: Saul, Meike J., et al.
Publicado: (2019)

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
por: Rappl, Peter, et al.
Publicado: (2021)

Targeting mPGES-1 as a New Strategy against Neuroblastoma
por: Comunanza, Valentina
Publicado: (2018)

Analgesic effects of a highly selective mPGES-1 inhibitor
por: Stewart, Madeline J., et al.
Publicado: (2023)

Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
por: Radi, Zaher A., et al.
Publicado: (2007)

Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
por: Takeda, H, et al.
Publicado: (2004)

Transcriptional regulation of the mPGES-1 gene in primary cultured articular chondrocytes
por: Bausero, P, et al.
Publicado: (2004)

mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice
por: Brenneis, Christian, et al.
Publicado: (2008)

Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent
por: Kothavade, Pankaj S., et al.
Publicado: (2013)

The role of mPGES-1 for prostaglandin E(2 )production in primary human synovial cells
por: Crofford, L, et al.
Publicado: (2003)

Role of COX-2/mPGES-1/Prostaglandin E2 Cascade in Kidney Injury
por: Jia, Zhanjun, et al.
Publicado: (2015)

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
por: Noha, Stefan M., et al.
Publicado: (2015)

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
por: de Oliveira, Antonio Carlos Pinheiro, et al.
Publicado: (2016)

The Augmenting Effects of Desolvation and Conformational Energy Terms on the Predictions of Docking Programs against mPGES-1
por: Gupta, Ashish, et al.
Publicado: (2015)

CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors
por: Chen, Zhanfei, et al.
Publicado: (2019)

Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene
por: Gosset, Marjolaine, et al.
Publicado: (2006)

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
por: de Oliveira, Antonio CP, et al.
Publicado: (2012)

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity
por: Finetti, Federica, et al.
Publicado: (2015)

DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
por: Zhou, Shuo, et al.
Publicado: (2020)

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition
por: Di Micco, Simone, et al.
Publicado: (2021)

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome
por: Luo, Qimei, et al.
Publicado: (2021)

Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine
por: Wang, Wenfei, et al.
Publicado: (2022)

Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids
por: Steinmetz, Julia, et al.
Publicado: (2020)

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)
por: Waltenberger, Birgit, et al.
Publicado: (2011)

COX-2 but Not mPGES-1 Contributes to Renal PGE2 Induction and Diabetic Proteinuria in Mice with Type-1 Diabetes
por: Jia, Zhanjun, et al.
Publicado: (2014)

Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
por: Pierre, Clément, et al.
Publicado: (2018)

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
por: Zhu, Liyuan, et al.
Publicado: (2019)

PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice
por: Sun, Ying, et al.
Publicado: (2013)

Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE(2) Cascade
por: Wang, Haiping, et al.
Publicado: (2015)

mPGES-1-Mediated Production of PGE(2) and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation
por: Maseda, Damian, et al.
Publicado: (2018)

Effect of Proton Pump Inhibitor Therapy on NOX5, mPGES1 and iNOS expression in Barrett’s Esophagus
por: Li, Dan, et al.
Publicado: (2019)

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor
por: Di Micco, Simone, et al.
Publicado: (2022)

COX-2/mPGES-1/PGE(2) cascade activation mediates uric acid-induced mesangial cell proliferation
por: Li, Shuzhen, et al.
Publicado: (2016)

mPGES-1 Inhibitor Discovery Based on Computer-Aided Screening: Pharmacophore Models, Molecular Docking, ADMET, and MD Simulations
por: Huang, Qiqi, et al.
Publicado: (2023)

Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis
por: Li, Ting, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ns0k9egkvo0ke24gg82vcmn9nn