The SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C

R-loops, three-stranded DNA-DNA:RNA hybrid structures, are best known for their deleterious effects on genome stability. The regulatory factors of this fundamental genetic structure remain unclear. Here, we reveal an epigenetic factor that controls R-loop stability. METTL8, a member of the methyltra...

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Detalles Bibliográficos
Autores principales: Zhang, Li-Hong, Zhang, Xue-Yun, Hu, Tao, Chen, Xin-Yun, Li, Jing-Jia, Raida, Manfred, Sun, Ning, Luo, Yan, Gao, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082549/
https://www.ncbi.nlm.nih.gov/pubmed/32199293
http://dx.doi.org/10.1016/j.isci.2020.100968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082549/
https://www.ncbi.nlm.nih.gov/pubmed/32199293
http://dx.doi.org/10.1016/j.isci.2020.100968

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